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Mucin-Type Glycopeptide Structure in Solution: Past, Present, and Future
Article first published online: 27 JUL 2013
Published 2013 Wiley Periodicals, Inc. This article is a U.S. Government work and, as such, is in the public domain in the United States of America.
Special Issue: 50th Anniversary Special Issue on Glycosciences
Volume 99, Issue 10, pages 713–723, October 2013
How to Cite
Barchi, J. J. (2013), Mucin-Type Glycopeptide Structure in Solution: Past, Present, and Future. Biopolymers, 99: 713–723. doi: 10.1002/bip.22313
- Issue published online: 27 JUL 2013
- Article first published online: 27 JUL 2013
- Accepted manuscript online: 13 JUN 2013 01:44PM EST
- Manuscript Accepted: 5 JUN 2013
- Manuscript Received: 2 JUN 2013
- O-linked glycans;
Mucins are very high molecular weight glycoproteins that form a “mucus” barrier at the surface of epithelial cells. They are heavily glycosylated with O-linked glycans that are involved in myriad cellular functions, including protection from external changes in pH, ion flux and reactive oxygen species. Aberrations in mucin expression and their glycan constitution have been associated with many disease states including gastritis, pulmonary disorders and cancer. High resolution structural information on mucins is lacking due to their complexity, in particular their large size and the many variants of O-linked glycans produced in their biosynthesis. This review discusses the structures of glycopeptides that contain “mucin-type” glycosylation, and concentrates primarily on data obtained by NMR spectroscopy. The effect of the glycan on the peptide backbone, the features that have shown to be common to this type of glycosylation and the differences of glycosylation at serine and threonine residues are the major topics of discussion. Published 2013 Wiley Periodicals, Inc. Biopolymers 99: 713–723, 2013.