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Elongation factor P: Function and effects on bacterial fitness
Article first published online: 28 AUG 2013
Copyright © 2013 Wiley Periodicals, Inc.
Special Issue: 50th Anniversary Special Issue on Proteins
Volume 99, Issue 11, pages 837–845, November 2013
How to Cite
Doerfel, L. K. and Rodnina, M. V. (2013), Elongation factor P: Function and effects on bacterial fitness. Biopolymers, 99: 837–845. doi: 10.1002/bip.22341
- Issue published online: 28 AUG 2013
- Article first published online: 28 AUG 2013
- Accepted manuscript online: 5 JUL 2013 03:23AM EST
- Manuscript Accepted: 19 JUN 2013
- Manuscript Received: 6 JUN 2013
- Max Planck Society, Deutsche Forschungsgemeinschaft
- translation factors;
The elongation phase of translation is promoted by three universal elongation factors, EF-Tu, EF-Ts, and EF-G in bacteria and their homologs in archaea and eukaryotes. Recent findings demonstrate that the translation of a subset of mRNAs requires a fourth elongation factor, EF-P in bacteria or the homologs factors a/eIF5A in other kingdoms of life. EF-P prevents the ribosome from stalling during the synthesis of proteins containing consecutive Pro residues, such as PPG, PPP, or longer Pro clusters. The efficient and coordinated synthesis of such proteins is required for bacterial growth, motility, virulence, and stress response. EF-P carries a unique post-translational modification, which contributes to its catalytic proficiency. The modification enzymes, which are lacking in higher eukaryotes, provide attractive new targets for the development of new, highly specific antimicrobials. © 2013 Wiley Periodicals, Inc. Biopolymers 99: 837–845, 2013.