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Review collagen-based biomaterials for wound healing
Version of Record online: 26 MAY 2014
© 2014 Wiley Periodicals, Inc.
Volume 101, Issue 8, pages 821–833, August 2014
How to Cite
Chattopadhyay, S., Raines, R. T. (2014), Review collagen-based biomaterials for wound healing. Biopolymers, 101: 821–833. doi: 10.1002/bip.22486
- Issue online: 26 MAY 2014
- Version of Record online: 26 MAY 2014
- Accepted manuscript online: 14 MAR 2014 04:36AM EST
- Manuscript Accepted: 7 MAR 2014
- Manuscript Received: 24 FEB 2014
- NIH . Grant Number: R01 AR044276 and RC2 AR058971
- extracellular matrix;
- regenerative medicine
With its wide distribution in soft and hard connective tissues, collagen is the most abundant of animal proteins. In vitro, natural collagen can be formed into highly organized, three-dimensional scaffolds that are intrinsically biocompatible, biodegradable, nontoxic upon exogenous application, and endowed with high tensile strength. These attributes make collagen the material of choice for wound healing and tissue engineering applications. In this article, we review the structure and molecular interactions of collagen in vivo; the recent use of natural collagen in sponges, injectables, films and membranes, dressings, and skin grafts; and the on-going development of synthetic collagen mimetic peptides as pylons to anchor cytoactive agents in wound beds. © 2014 Wiley Periodicals, Inc. Biopolymers 101: 821–833, 2014.