Get access

Processing/structure/property relationship of multi-scaled PCL and PCL–HA composite scaffolds prepared via gas foaming and NaCl reverse templating

Authors

  • A. Salerno,

    Corresponding author
    1. Interdisciplinary Research Centre on Biomaterials (CRIB), Italian Institute of Technology (IIT), University of Naples Federico II, Piazz.le Tecchio 80, 80125 Naples, Italy; telephone: +390817682536; fax: +390817682408
    2. Institute of Composite and Biomedical Materials and National Research Council (IMCB-CNR), University of Naples Federico II, Piazz.le Tecchio 80, 80125 Naples, Italy
    • Interdisciplinary Research Centre on Biomaterials (CRIB), Italian Institute of Technology (IIT), University of Naples Federico II, Piazz.le Tecchio 80, 80125 Naples, Italy; telephone: +390817682536; fax: +390817682408.
    Search for more papers by this author
  • S. Zeppetelli,

    1. Institute of Composite and Biomedical Materials and National Research Council (IMCB-CNR), University of Naples Federico II, Piazz.le Tecchio 80, 80125 Naples, Italy
    Search for more papers by this author
  • E. Di Maio,

    1. Department of Materials and Production Engineering (DIMP), University of Naples Federico II, Piazz.le Tecchio 80, 80125 Naples, Italy
    Search for more papers by this author
  • S. Iannace,

    1. Institute of Composite and Biomedical Materials and National Research Council (IMCB-CNR), University of Naples Federico II, Piazz.le Tecchio 80, 80125 Naples, Italy
    Search for more papers by this author
  • P.A. Netti

    1. Interdisciplinary Research Centre on Biomaterials (CRIB), Italian Institute of Technology (IIT), University of Naples Federico II, Piazz.le Tecchio 80, 80125 Naples, Italy; telephone: +390817682536; fax: +390817682408
    2. Department of Materials and Production Engineering (DIMP), University of Naples Federico II, Piazz.le Tecchio 80, 80125 Naples, Italy
    Search for more papers by this author

Abstract

In this study, we investigated the processing/structure/property relationship of multi-scaled porous biodegradable scaffolds prepared by combining the gas foaming and NaCl reverse templating techniques. Poly(ε-caprolactone) (PCL), hydroxyapatite (HA) nano-particles and NaCl micro-particles were melt-mixed by selecting different compositions and subsequently gas foamed by a pressure-quench method. The NaCl micro-particles were finally removed from the foamed systems in order to allow for the achievement of the multi-scaled scaffold pore structure. The control of the micro-structural properties of the scaffolds was obtained by the optimal combination of the NaCl templating concentration and the composition of the CO2–N2 mixture as the blowing agent. In particular, these parameters were accurately selected to allow for the fabrication of PCL and PCL–HA composite scaffolds with multi-scaled open pore structures. Finally, the biocompatibility of the scaffolds has been assessed by cultivating pre-osteoblast MG63 cells in vitro, thus demonstrating their potential applications for bone regeneration. Biotechnol. Bioeng. 2011; 108:963–976. © 2010 Wiley Periodicals, Inc.

Get access to the full text of this article

Ancillary