Article
You have free access to this content
Fed-batch and perfusion culture processes: Economic, environmental, and operational feasibility under uncertainty
Article first published online: 6 AUG 2012
DOI: 10.1002/bit.24608
Copyright © 2012 Wiley Periodicals, Inc.
Additional Information
How to Cite
Pollock, J., Ho, S. V. and Farid, S. S. (2013), Fed-batch and perfusion culture processes: Economic, environmental, and operational feasibility under uncertainty. Biotechnol. Bioeng., 110: 206–219. doi: 10.1002/bit.24608
Publication History
- Issue published online: 20 NOV 2012
- Article first published online: 6 AUG 2012
- Accepted manuscript online: 13 JUL 2012 08:34AM EST
- Manuscript Revised: 5 JUL 2012
- Manuscript Accepted: 5 JUL 2012
- Manuscript Received: 2 APR 2012
References
- , , . 2008. How to construct a monoclonal antibody factory: A comparison of production costs in fed batch and perfusion culture with microcarriers—Part two. Bioprocess J 7(2): 30–43.
- . 2007. Perfusion or fed-batch? A matter of perspective. In: Butler M, editor. Cell culture and upstream processing. London, UK: Taylor Francis Group. p 173–184.
- , , . 2009. Perfusion! Jeopardy or the ultimate advantage? Bioprocess Int Webinar, October.
- . 2006. http://www.epa.ie/licences/lic_eDMS/090151b2800c1411.pdf (accessed 2011).
- , , . 2008. Process for cell culturing by continuous perfuison and alternating tangential flow patent 20080131934.
- . 2008. Multi-objective optimization using evolutionary algorithms. New Jersey: John Wiley & Sons, Ltd.
- , , . 1996. Practical considerations in operation and scale-up of spin-filter based bioreactors for monoclonal antibody production. Biotechnol Prog 12(1): 57–64.
- . 2006. Established bioprocesses for producing antibodies as a basis for future planning. Cell Cult Eng 101: 1–42.
- . 2007. Process economics of industrial monoclonal antibody manufacture. J Chromatogr B Anal Technol Biomed Life Sci 848(1): 8–18.
- . 2009a. Economic drivers and trade-offs in antibody purification processes. Bio Pharm Int S38–S42.
- . 2009b. Process economics drivers in industrial monoclonal antibody manufacture. In: Gottschalk U, editor. Process scale purification of antibodies. New Jersey: John Wiley & Sons, Inc. p 239–262.
- , , , , . 2000. A tool for modeling strategic decisions in cell culture manufacturing. Biotechnol Prog 16(5): 829–836.
- , , . 2005. Decision-support tool for assessing biomanufacturing strategies under uncertainty: Stainless steel versus disposable equipment for clinical trial material preparation. Biotechnol Prog 21(2): 486–497.
- , , . 2007. Modelling biopharmaceutical manufacture: Design and implementation of SimBiopharma. Comput Chem Eng 31(9): 1141–1158.
- , , , . 2011. Toward Greener therapeutic proteins. In: Tao J, Kazlazuskas R, editors. Biocatalysis for Grenn Chemistry and Chemical Process Development. New Jersey: John Wiley & Sons. p 197–219.
- , . 1981. Multiple attribute decision making—Methods and applications. A state-of-the-art survey. lecture notes in economics and mathmatical systems. Berlin, Heidelberg, New York: Springer Verlag.
- . 2009. Industrialization of mAb production technology. The bioprocessing industry at a crossroads. Mabs 1(5): 443–452.
- . 2007. Very large scale monoclonal antibody purification: The case for conventional unit operations. Biotechnol Prog 23(5): 995–1008.
- , , , . 2006. A computer-aided approach to compare the production economics of fed-batch and perfusion culture under uncertainty. Biotechnol Bioeng 93(4): 687–697.
- , , , , , , , . 2005. Application of a decision-support tool to assess pooling strategies in perfusion culture processes under uncertainty. Biotechnol Prog 21(4): 1231–1242.
- , , , . 2010. Recovery and purification process development for monoclonal antibody production. Mabs 2: 5.
- , , . 2001. Economic comparison between conventional and disposables-based technology for the production of biopharmaceuticals. Biotechnology Bioeng 75(2): 143–153.
- , . 2004. Simulations improve produciton capacity. BioPharm Int, May.
- , , , , . 2010. Technological progresses in monoclonal antibody production systems. Biotechnol Prog 26(2): 332–351.
- , , , . 2001. Selection of bioprocess simulation software for industrial applications. Biotechnol Bioeng 72(4): 483–489.
- . 2007. The E factor: Fifteen years on. Green Chem 9(12): 1273–1283.
- . 2000. Fluid filtration system patent 6544424.
- , , , . 2009. Dynamic simulation framework for design of lean biopharmaceutical manufacturing operations. Computer-Aided Chemical Engineering Series; 2009. Amesterdam: Elsevier B. V. Ltd. p 1069–1074.
- . 2000. Multi-criteria decision making methods: A comparative study. Netherlands: Kluwer Acadmic Publishers.
- , , , , . 2007. An on-line method for the reduction of fouling of spin-filters for animal cell perfusion cultures. J Biotechnol 130(3): 265–273.
- , , , , . 2003. Potential of cell retention techniques for large-scale high-density perfusion culture of suspended mammalian cells. Biotechnol Bioeng 82(7): 751–765.
- , , , , , , . 2007. Making changes to a biopharmaceutical process during development and commercial manufacturing: The REMICADE story. In: Shukla AA, Etzel MR, Gadam S, editors. Process scale bioseperations for the biophamceutical industry. London, UK: Taylor Francis Group. p 507–523.
- , , . 1992. Mammalian cell retention in a spinfilter perfusion bioreactor. Biotechnol Bioeng 40(8): 925–933.

1097-0290/asset/BIT_left.gif?v=1&s=5f6054ce9ff7b0421e44e8e4e33966356f37b71c)
