Article

Chitosan-heparin polyelectrolyte multilayers on cortical bone: Periosteum-mimetic, cytophilic, antibacterial coatings

  1. Jorge Almodóvar1,
  2. Justin Mower2,
  3. Apurba Banerjee3,
  4. Ajoy K. Sarkar4,
  5. Nicole P. Ehrhart5,
  6. Matt J. Kipper2,*

Article first published online: 1 SEP 2012

DOI: 10.1002/bit.24710

Issue

Biotechnology and Bioengineering

Biotechnology and Bioengineering

Volume 110, Issue 2, pages 609–618, February 2013

Additional Information

How to Cite

Almodóvar, J., Mower, J., Banerjee, A., Sarkar, A. K., Ehrhart, N. P. and Kipper, M. J. (2013), Chitosan-heparin polyelectrolyte multilayers on cortical bone: Periosteum-mimetic, cytophilic, antibacterial coatings. Biotechnol. Bioeng., 110: 609–618. doi: 10.1002/bit.24710

Author Information

  1. 1

    Grenoble Institute of Technology, LMGP, CNRS, Grenoble, France

  2. 2

    Department of Chemical and Biological Engineering, and School of Biomedical Engineering, Colorado State University, 1370 Campus Delivery, Fort Collins, Colorado 80523-1370; telephone: 970-491-0870; fax: 970-491-7369

  3. 3

    Department of Design and Merchandising, Colorado State University, Fort Collins, Colorado

  4. 4

    Department of Textile Development and Marketing, Fashion Institute of Technology, State University of New York, New York, NY

  5. 5

    Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado

*Department of Chemical and Biological Engineering, and School of Biomedical Engineering, Colorado State University, 1370 Campus Delivery, Fort Collins, Colorado 80523-1370; telephone: 970-491-0870; fax: 970-491-7369

Publication History

  1. Issue published online: 20 DEC 2012
  2. Article first published online: 1 SEP 2012
  3. Accepted manuscript online: 17 AUG 2012 08:39AM EST
  4. Manuscript Accepted: 7 AUG 2012
  5. Manuscript Revised: 5 AUG 2012
  6. Manuscript Received: 8 JUN 2012

Funded by

  • National Science Foundation. Grant Number: DMR 0847641
  • Musculoskeletal Transplant Foundation.

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (1403K)

Keywords:

  • biomimetic;
  • mesenchymal stem cells;
  • layer-by-layer;
  • glycosaminoglycans;
  • XPS;
  • bone allograft

Abstract

Cortical bone allografts suffer from high rates of failure due to poor integration with host tissue, leading to non-union, fracture, and infection following secondary procedures. Here, we report a method for modifying the surfaces of cortical bone with coatings that have biological functions that may help overcome these challenges. These chitosan-heparin coatings promote mesenchymal stem cell attachment and have significant antibacterial activity against both S. aureus and E. coli. Furthermore, their chemistry is similar to coatings we have reported on previously, which effectively stabilize and deliver heparin-binding growth factors. These coatings have potential as synthetic periosteum for improving bone allograft outcomes. Biotechnol. Bioeng. 2013; 110: 609–618. © 2012 Wiley Periodicals, Inc.

View Full Article with Supporting Information (HTML) Get PDF (1403K)