Chitosan-heparin polyelectrolyte multilayers on cortical bone: Periosteum-mimetic, cytophilic, antibacterial coatings
Article first published online: 1 SEP 2012
Copyright © 2012 Wiley Periodicals, Inc.
Biotechnology and Bioengineering
Volume 110, Issue 2, pages 609–618, February 2013
How to Cite
Almodóvar, J., Mower, J., Banerjee, A., Sarkar, A. K., Ehrhart, N. P. and Kipper, M. J. (2013), Chitosan-heparin polyelectrolyte multilayers on cortical bone: Periosteum-mimetic, cytophilic, antibacterial coatings. Biotechnol. Bioeng., 110: 609–618. doi: 10.1002/bit.24710
- Issue published online: 20 DEC 2012
- Article first published online: 1 SEP 2012
- Accepted manuscript online: 17 AUG 2012 08:39AM EST
- Manuscript Accepted: 7 AUG 2012
- Manuscript Revised: 5 AUG 2012
- Manuscript Received: 8 JUN 2012
- National Science Foundation. Grant Number: DMR 0847641
- Musculoskeletal Transplant Foundation.
- mesenchymal stem cells;
- bone allograft
Cortical bone allografts suffer from high rates of failure due to poor integration with host tissue, leading to non-union, fracture, and infection following secondary procedures. Here, we report a method for modifying the surfaces of cortical bone with coatings that have biological functions that may help overcome these challenges. These chitosan-heparin coatings promote mesenchymal stem cell attachment and have significant antibacterial activity against both S. aureus and E. coli. Furthermore, their chemistry is similar to coatings we have reported on previously, which effectively stabilize and deliver heparin-binding growth factors. These coatings have potential as synthetic periosteum for improving bone allograft outcomes. Biotechnol. Bioeng. 2013; 110: 609–618. © 2012 Wiley Periodicals, Inc.