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Chitosan-heparin polyelectrolyte multilayers on cortical bone: Periosteum-mimetic, cytophilic, antibacterial coatings

Authors

  • Jorge Almodóvar,

    1. Grenoble Institute of Technology, LMGP, CNRS, Grenoble, France
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  • Justin Mower,

    1. Department of Chemical and Biological Engineering, and School of Biomedical Engineering, Colorado State University, 1370 Campus Delivery, Fort Collins, Colorado 80523-1370; telephone: 970-491-0870; fax: 970-491-7369
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  • Apurba Banerjee,

    1. Department of Design and Merchandising, Colorado State University, Fort Collins, Colorado
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  • Ajoy K. Sarkar,

    1. Department of Textile Development and Marketing, Fashion Institute of Technology, State University of New York, New York, NY
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  • Nicole P. Ehrhart,

    1. Department of Clinical Sciences, Colorado State University, Fort Collins, Colorado
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  • Matt J. Kipper

    Corresponding author
    1. Department of Chemical and Biological Engineering, and School of Biomedical Engineering, Colorado State University, 1370 Campus Delivery, Fort Collins, Colorado 80523-1370; telephone: 970-491-0870; fax: 970-491-7369
    • Department of Chemical and Biological Engineering, and School of Biomedical Engineering, Colorado State University, 1370 Campus Delivery, Fort Collins, Colorado 80523-1370; telephone: 970-491-0870; fax: 970-491-7369
    Search for more papers by this author

Abstract

Cortical bone allografts suffer from high rates of failure due to poor integration with host tissue, leading to non-union, fracture, and infection following secondary procedures. Here, we report a method for modifying the surfaces of cortical bone with coatings that have biological functions that may help overcome these challenges. These chitosan-heparin coatings promote mesenchymal stem cell attachment and have significant antibacterial activity against both S. aureus and E. coli. Furthermore, their chemistry is similar to coatings we have reported on previously, which effectively stabilize and deliver heparin-binding growth factors. These coatings have potential as synthetic periosteum for improving bone allograft outcomes. Biotechnol. Bioeng. 2013; 110: 609–618. © 2012 Wiley Periodicals, Inc.

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