A new method of fabricating robust freeform 3D ceramic scaffolds for bone tissue regeneration

Authors

  • Young-Joon Seol,

    1. Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja dong, Nam-gu, Pohang, Gyungbuk, 790-784, Korea; telephone: 82-54-279-2182; fax: 82-54-279-5899 (S.J. Park); telephone: 82-54-279-2171; fax: 82-54-279-5419 (D.-W. Cho)
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  • Dong Yong Park,

    1. Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja dong, Nam-gu, Pohang, Gyungbuk, 790-784, Korea; telephone: 82-54-279-2182; fax: 82-54-279-5899 (S.J. Park); telephone: 82-54-279-2171; fax: 82-54-279-5419 (D.-W. Cho)
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  • Ju Young Park,

    1. Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), San 31, Hyoja dong, Nam-gu, Pohang, Gyungbuk, 790-784, Korea
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  • Sung Won Kim,

    1. Department of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, College of Medicine, 505 Banpodong, Seocho-gu, Seoul, 137-040, Korea
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  • Seong Jin Park,

    Corresponding author
    1. Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja dong, Nam-gu, Pohang, Gyungbuk, 790-784, Korea; telephone: 82-54-279-2182; fax: 82-54-279-5899 (S.J. Park); telephone: 82-54-279-2171; fax: 82-54-279-5419 (D.-W. Cho)
    2. Division of Advanced Nuclear Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja dong, Nam-gu, Pohang, Gyungbuk, 790-784, Korea
    • Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja dong, Nam-gu, Pohang, Gyungbuk, 790-784, Korea; telephone: 82-54-279-2182; fax: 82-54-279-5899 (S.J. Park); telephone: 82-54-279-2171; fax: 82-54-279-5419 (D.-W. Cho).
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  • Dong-Woo Cho

    Corresponding author
    1. Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja dong, Nam-gu, Pohang, Gyungbuk, 790-784, Korea; telephone: 82-54-279-2182; fax: 82-54-279-5899 (S.J. Park); telephone: 82-54-279-2171; fax: 82-54-279-5419 (D.-W. Cho)
    2. Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), San 31, Hyoja dong, Nam-gu, Pohang, Gyungbuk, 790-784, Korea
    • Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), San 31, Hyoja dong, Nam-gu, Pohang, Gyungbuk, 790-784, Korea; telephone: 82-54-279-2182; fax: 82-54-279-5899 (S.J. Park); telephone: 82-54-279-2171; fax: 82-54-279-5419 (D.-W. Cho).
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  • Y.-J. Seol and D.Y. Park contributed equally to this work.

Abstract

Fabrication of three-dimensional (3D) scaffolds with appropriate mechanical properties and desired architecture for promoting cell growth and new tissue formation is one of the most important efforts in tissue engineering field. Scaffolds fabricated from bioactive ceramic materials such as hydroxyapatite and tricalcium phosphate show promise because of their biological ability to support bone tissue regeneration. However, the use of ceramics as scaffold materials is limited because of their inherent brittleness and difficult processability. The aim of this study was to create robust ceramic scaffolds, which have a desired architecture. Such scaffolds were successfully fabricated by projection-based microstereolithography, and dilatometric analysis was conducted to study the sintering behavior of the ceramic materials. The mechanical properties of the scaffolds were improved by infiltrating them with a polycaprolactone solution. The toughness and compressive strength of these ceramic/polymer scaffolds were about twice those of ceramic scaffolds. Furthermore, the osteogenic gene expression on ceramic/polymer scaffolds was better than that on ceramic scaffolds. Through this study, we overcame the limitations of previous research on fabricating ceramic scaffolds and these new robust ceramic scaffolds may provide a much improved 3D substrate for bone tissue regeneration. Biotechnol. Bioeng. 2013; 110: 1444–1455. © 2012 Wiley Periodicals, Inc.

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