Dynamics of microbial propagation: Models considering inhibitors and variable cell composition
Article first published online: 18 FEB 2004
Copyright © 1967 John Wiley & Sons, Inc.
Biotechnology and Bioengineering
Volume 9, Issue 2, pages 129–170, April 1967
How to Cite
Ramkrishna, D., Fredrickson, A. G. and Tsuchiya, H. M. (1967), Dynamics of microbial propagation: Models considering inhibitors and variable cell composition. Biotechnol. Bioeng., 9: 129–170. doi: 10.1002/bit.260090203
- Issue published online: 18 FEB 2004
- Article first published online: 18 FEB 2004
- Manuscript Received: 2 MAY 1966
Mathematical models for microbial growth in batch and continuous cultures are formulated. The models have been referred to as distributed models since the microbial population in a culture is looked upon as protoplasmic mass distributed uniformly throughout the culture. Growth is regarded as the increase in this mass by conversion of medium components into biological mass and metabolic products. Two sets of models have been presented. The first arise from introducing additional considerations into the model proposed by Monod to account for the stationary phase and the phase of decline in a batch culture. These have been referred to as unstructured, distributed models since they do not recognize any form of structure in the protoplasmic mass. The models in the second set are referred to as structured, distributed models. Structure is introduced by considering the protoplasmic mass to be composed of two groups of substances which interact with each other and with substances in the environment to produce growth. The structured models account for the dependence of growth on the past, history of the cells; thus they predict all growth phases observed in batch cultures, whereas the unstructured models do not predict a lag phase. The full implications of the models for continuous propagation, as determined by the method of stability analysis and transient calculations, are discussed. The models prediet a number of new results and should be confronted with experiments.