Computer model for glucose-limited growth of a single cell of Escherichia coli B/r-A
Article first published online: 18 FEB 2004
Copyright © 1984 John Wiley & Sons, Inc.
Biotechnology and Bioengineering
Volume 26, Issue 3, pages 203–216, March 1984
How to Cite
Domach, M. M., Leung, S. K., Cahn, R. E., Cocks, G. G. and Shuler, M. L. (1984), Computer model for glucose-limited growth of a single cell of Escherichia coli B/r-A. Biotechnol. Bioeng., 26: 203–216. doi: 10.1002/bit.260260303
- Issue published online: 18 FEB 2004
- Article first published online: 18 FEB 2004
- Manuscript Accepted: 15 AUG 1983
A computer model is described which is capable of predicting changes in cell composition, cell size, cell shape, and the timing of chromosome synthesis in response to changes in external glucose limitation. The model is constructed primarily from information on unrestricted growth in glucose minimal medium. The ability of the model to make reasonable quantitative predictions under glucose-limitation is a test of the plausibility of the basic biochemical mechanisms included in the model. Such a model should be of use in differentiating among competing hypotheses for biological mechanisms and in suggesting as yet unobserved phenomena. The last two points are illustrated with the testing of a mechanism for the control of the initiation of DNA synthesis and predictions on cellwidth variations during the division cycle.