Pellet formation and cellular aggregation in Streptomyces tendae
Article first published online: 18 FEB 2004
Copyright © 1990 John Wiley & Sons, Inc.
Biotechnology and Bioengineering
Volume 35, Issue 9, pages 890–896, 15 April 1990
How to Cite
Vecht-Lifshitz, S. E., Magdassi, S. and Braun, S. (1990), Pellet formation and cellular aggregation in Streptomyces tendae. Biotechnol. Bioeng., 35: 890–896. doi: 10.1002/bit.260350906
- Issue published online: 18 FEB 2004
- Article first published online: 18 FEB 2004
- Manuscript Accepted: 29 SEP 1989
In submerged cultures, Streptomyces tendae tended to form fluffy spherical pellets of the noncoagulative type. An increase in the average pellet size could be attained by decreasing any of the following: shear rate, pH, temperature, or inoculum size. Conditions leading to oxygen limitation tended to reduce the average pellet size and induced pulpy growth, whereas oxygen sufficiency seemed to induce pellet formation. Factors inducing pellet formation simultaneously increased cell wall hydrophobicity. It is therefore proposed that the main forces inducing cellular aggregation in S. tendae are hydrophobic interactions of cell walls, and these interactions are controlled by availability of dissolved oxygen.