• 1
    Berr, F., Simon, F. R., Reichen, J. 1984. Ethynylestradiol impairs bile salt uptake and Na-K pamp function of rat hepatocytes. Am. J. Physiol. 247: G437443.
  • 2
    Bereiter-Hahn, J., Luck, M., Miebach, T., Stelzer, H. K., Voth, M. 1990. Spreading of trypsinized cells: Cytoskeletal dynamics and energy requirements. J. Cell. Sci. 96: 171188.
  • 3
    Campra, J. L., Reynold, T. B. 1988. The hepatic circulation. In M.Arias et al. (eds.), The liver biology and pathobiology, pp. 911930. Raven Press, New York.
  • 4
    Carlier, M. F., Pantaloni, D., Korn, E. D. 1987. The mechanism of ATP hydrolysi accompanying the polymerization of Mg-actin. J. Biol. Chem. 263: 30523059.
  • 5
    de Groot, H., Noll, T., Sies, H. 1985. Oxygen dependence and subcellular partitioning of hepatic menadion-mediated oxygen uptake. Arch. Biochem. Biophy. 243: 556562.
  • 6
    Dunn, J. C. Y., Yarmush, M. L., Koebe, H. G., Tompkins, R. G. 1989. Hepatocyte function and extracellular matrix geometry: Long-term culture in s sandwich configuration. FASEB J. 3: 174177.
  • 7
    Dunn, J. C. Y., Tompkins, R. G., Yarmush, M. L. 1991. Long-term in-vitro function of adult hepatocytes in a collagen sandwich configuration. Biotechnol. Progr. 7: 237245.
  • 8
    Dunn, J. C. Y. Tompkins, R. G., Yarmush, M. L. 1992. Hepatocytes in collagen sandwich: Evidence for transcriptional and translational regulation. J. Cell. Biol. 116: 10431053.
  • 9
    Elsdale, T., Bard, J. 1972. Collagen substrata for sutdies on cell behavior. J. Cell Biol. 54: 626637.
  • 10
    Ezzell, R., Toner, M., Hendricks, K., Dunn, J. C. Y., Tompkins, R. G., Yarmush, M. L. Cytoskeletal reorganization of hepatocyctes cultured between two layers of collagen. (to appear)
  • 11
    Hendricks, H. F. J. Brouwer, A., Knook, D. L. 1990. Isolation, purification, and characterization of liver cell types. Meth. Enzymol. 190: 4958.
  • 12
    Holiday, M. A. 1971. Metabolic rate and organ size during growth from infancy to maturity and during late gestation and early infancy. Pediatrics. 47: 169179.
  • 13
    Hummerich, H., de Groot, H., Noll, T., Soboll, S. 1988. Dependence of mitochondrial and cytosolic adenine nucleotides on oxygen partial pressure in isolated hepatocytes. Biochem. J. 250: 641645.
  • 14
    Gebhardt, R., Mecke, D. 1979. Perifused monolayer cultures of rat hepatocytes as an improved in-vitro system for studies on ureogenesis. Exp. Cell Res. 124: 349359.
  • 15
    Gordon, M. W., Kaplan, M. L. 1986. Oxygen consumption and oxidative capacity of hepatocytes from young male obese and non-obese. Proc. Soc. Exp. Biol. Med. 183: 199206.
  • 16
    Jones, D. P. 1984. Effect of mitochondria clustering on O2 supply in hepatocytes. Cell Physiol. 247: C8389.
  • 17
    Kreamer, B. L., Staecker, J. L., Sawada, N., Sattler, G. L., Hsia, M. T. S., Pitot, H. 1986. Use of low-speed, iso-density per-coll centrifugation method to increase viability of isolated rat hepatocyte preparations. In-Vitro Cell. Devel. Biol. 22: 201211.
  • 18
    Levenspiel, O. 1972. Chemical reaction engineering. 2nd edition. Wiley, New York.
  • 19
    Miura, Y., Akimoto, T., Fuke, Y., Yamazaki, S., Yagi, K. 1987. In-vitro maintenance of terminal-differential state in hepatocytes entrapped within calcium alginate. Artif. Org. 1: 361365.
  • 20
    Nobes, C. D., Hay, W. W., Brand, M. D. 1990. The mechanism of stimulation of respiration by fatty acids in isolated hepatocytes. J. Biol. Chem. 265: 1291012915.
  • 21
    Plomp, P. J. A. M., van Roermund, C. W. T., Groen, A. K., Meijer, A. L., Tager, J. M. 1985. Mechanism of the stimulation of respiration by fatty acids in rat liver. FEBS Lett. 193: 243246.
  • 22
    Seglen, P. O. 1976. Preparation of isolated rat liver cells. Meth. Biol. 13: 2983.
  • 23
    Suleiman, S. A., Stevens, J. B. 1987. The effect of oxygen tension on rat hepatocytes in short-term culture. In-Vitro Cell. Devel. Biol. 23: 332337.
  • 24
    Uchino, J., Tsuburaya, T., Kumagai, F., Hase, T., Hamada, T., Komai, T., Funatsu, T., Hashimura, E., Nakamura, K., Kon, T. 1988. A hybrid bioartificial liver composed of multiplied hepatocyte monolayers. ASAIO Trans. 34: 972977.
  • 25
    Watanabe, N., Tsukada, N., Smith, C. R., Edwards, V., Philips, M. J. 1991. Permeabilized hapatocyle couplets. Lab. Invest. 65: 203213.
  • 26
    Yarmush, M. L., Toner, M., Dunn, J. C. Y., Rotem, A., Hubel, A., Lee, J., Tompkins, R. G. Hepatic tissue engineering: Development of critical technologies. Ann. NY Acad. Sci. (to appear).