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Biotechnology and Bioengineering

Copyright © 2013 Wiley Periodicals, Inc., A Wiley Company

Cover image for Vol. 105 Issue 2

1 February 2010

Volume 105, Issue 2

Pages fmv–fmv, 221–438

  1. Spotlights

    1. Top of page
    2. Spotlights
    3. Articles
    4. Communications to the Editor
    1. Delivering high capacity, yield, and resolution (page fmv)

      Article first published online: 21 DEC 2009 | DOI: 10.1002/bit.22620

    2. 2D-DIGE: A new paradigm in profiling host cell proteins during bioprocess development (page fmv)

      Article first published online: 21 DEC 2009 | DOI: 10.1002/bit.22640

    3. DIGE approach to investigate the effects of Bcl-xL overexpression (page fmv)

      Article first published online: 21 DEC 2009 | DOI: 10.1002/bit.22622

    4. Mathematical modeling to aid in drug formulation (page fmv)

      Article first published online: 21 DEC 2009 | DOI: 10.1002/bit.22639

  2. Articles

    1. Top of page
    2. Spotlights
    3. Articles
    4. Communications to the Editor

    1. Biocatalysis, Protein Engineering, and Nanobiotechnology

      High stability of self-assembled peptide nanowires against thermal, chemical, and proteolytic attacks (pages 221–230)

      Jungki Ryu and Chan Beum Park

      Article first published online: 23 SEP 2009 | DOI: 10.1002/bit.22544

    2. Biofuels and Environmental Biotechnology

      Engineering of a high-throughput screening system to identify cellulosic biomass, pretreatments, and enzyme formulations that enhance sugar release (pages 231–238)

      Michael H. Studer, Jaclyn D. DeMartini, Simone Brethauer, Heather L. McKenzie and Charles E. Wyman

      Article first published online: 3 SEP 2009 | DOI: 10.1002/bit.22527

    3. Bioprocess Engineering and Supporting Technologies

      Integrated solution to purification challenges in the manufacture of a soluble recombinant protein in E. coli (pages 239–249)

      Maire H. Caparon, Kevin J. Rust, Alan K. Hunter, Joseph K. McLaughlin, Kristen E. Thomas, John T. Herberg, Robert E. Shell, Paul B. Lanter, Bruce F. Bishop, Robert L. Dufield, Xing Wang and Sa V. Ho

      Article first published online: 23 SEP 2009 | DOI: 10.1002/bit.22542

    4. An unbiased sensitivity analysis reveals important parameters controlling periodicity of circadian clock (pages 250–259)

      Zhi Xie, Don Kulasiri, Sandhya Samarasinghe and Jiang Qian

      Article first published online: 23 SEP 2009 | DOI: 10.1002/bit.22540

    5. Microwell engineering characterization for mammalian cell culture process development (pages 260–275)

      Timothy A. Barrett, Andrew Wu, Hu Zhang, M. Susana Levy and Gary J. Lye

      Article first published online: 8 SEP 2009 | DOI: 10.1002/bit.22531

    6. Bioseparations and Downstream Processing

      Process analytical technology (PAT) for biopharmaceutical products: Part I. concepts and applications (pages 276–284)

      E.K. Read, J.T. Park, R.B. Shah, B.S. Riley, K.A. Brorson and A.S. Rathore

      Article first published online: 3 SEP 2009 | DOI: 10.1002/bit.22528

    7. Process analytical technology (PAT) for biopharmaceutical products: Part II. Concepts and applications (pages 285–295)

      E.K. Read, R.B. Shah, B.S. Riley, J.T. Park, K.A. Brorson and A.S. Rathore

      Article first published online: 3 SEP 2009 | DOI: 10.1002/bit.22529

    8. Development of a polishing step using a hydrophobic interaction membrane adsorber with a PER.C6®-derived recombinant antibody (pages 296–305)

      Michael Kuczewski, Nathalie Fraud, Rene Faber and Gregory Zarbis-Papastoitsis

      Article first published online: 8 SEP 2009 | DOI: 10.1002/bit.22538

    9. Profiling of host cell proteins by two-dimensional difference gel electrophoresis (2D-DIGE): Implications for downstream process development (pages 306–316)

      Mi Jin, Nicolas Szapiel, Jennifer Zhang, John Hickey and Sanchayita Ghose

      Article first published online: 8 SEP 2009 | DOI: 10.1002/bit.22532

    10. Cellular and Metabolic Engineering

      Metabolic flux analysis for recombinant protein production by Pichia pastoris using dual carbon sources: Effects of methanol feeding rate (pages 317–329)

      Eda Çelik, Pınar Çalık and Stephen G. Oliver

      Article first published online: 23 SEP 2009 | DOI: 10.1002/bit.22543

    11. BAK and BAX deletion using zinc-finger nucleases yields apoptosis-resistant CHO cells (pages 330–340)

      Gregory J. Cost, Yevgeniy Freyvert, Annamaria Vafiadis, Yolanda Santiago, Jeffrey C. Miller, Edward Rebar, Trevor N. Collingwood, Andrew Snowden and Philip D. Gregory

      Article first published online: 23 SEP 2009 | DOI: 10.1002/bit.22541

    12. Enhanced protein production using HBV X protein (HBx), and synergy when used in combination with XBP1s in BHK21 cells (pages 341–349)

      Fang Jin, Peter J. Kretschmer, Richard N. Harkins and Terry W. Hermiston

      Article first published online: 8 SEP 2009 | DOI: 10.1002/bit.22536

    13. Rapid production of recombinant human IgG With improved ADCC effector function in a transient expression system (pages 350–357)

      Patrick H.C. van Berkel, Jolanda Gerritsen, Edwin van Voskuilen, Gerrard Perdok, Tom Vink, Jan G.J. van de Winkel and Paul W.H.I. Parren

      Article first published online: 8 SEP 2009 | DOI: 10.1002/bit.22535

    14. A DIGE approach for the assessment of differential expression of the CHO proteome under sodium butyrate addition: Effect of Bcl-xL overexpression (pages 358–367)

      Jong Youn Baik and Gyun Min Lee

      Article first published online: 8 SEP 2009 | DOI: 10.1002/bit.22534

    15. Systems Biotechnology

      Cell placement and guidance on substrates for neurochip interfaces (pages 368–373)

      Anne Charrier, Dolores Martinez, Robert Monette, Tanya Comas, Raluca Movileanu, Christophe Py, Mike Denhoff, Anthony Krantis and Geoff Mealing

      Article first published online: 14 SEP 2009 | DOI: 10.1002/bit.22539

    16. Prediction of protein solubility in Escherichia coli using logistic regression (pages 374–383)

      Armando A. Diaz, Emanuele Tomba, Reese Lennarson, Rex Richard, Miguel J. Bagajewicz and Roger G. Harrison

      Article first published online: 8 SEP 2009 | DOI: 10.1002/bit.22537

    17. Tissue Engineering and Delivery Systems

      Serum-free, chemically defined medium with TGF-β3 enhances functional properties of nucleus pulposus cell-laden carboxymethylcellulose hydrogel constructs (pages 384–395)

      Anna T. Reza and Steven B. Nicoll

      Article first published online: 23 SEP 2009 | DOI: 10.1002/bit.22545

    18. Development of an Ibuprofen-releasing biodegradable PLA/PGA electrospun scaffold for tissue regeneration (pages 396–408)

      Irene Cantón, Robert Mckean, Mirren Charnley, Keith A. Blackwood, Calogero Fiorica, Anthony J. Ryan and Sheila MacNeil

      Article first published online: 3 SEP 2009 | DOI: 10.1002/bit.22530

    19. Modeling the influence of cyclodextrins on oral absorption of low-solubility drugs: I. Model development (pages 409–420)

      Ece Dilber Gamsiz, Lee Miller, Avinash G. Thombre, Imran Ahmed and Rebecca Lyn Carrier

      Article first published online: 1 SEP 2009 | DOI: 10.1002/bit.22523

    20. Modeling the influence of cyclodextrins on oral absorption of low solubility drugs: II. Experimental validation (pages 421–430)

      Ece Dilber Gamsiz, Lee Miller, Avinash G. Thombre, Imran Ahmed and Rebecca Lyn Carrier

      Article first published online: 1 SEP 2009 | DOI: 10.1002/bit.22524

  3. Communications to the Editor

    1. Top of page
    2. Spotlights
    3. Articles
    4. Communications to the Editor

    1. Systems Biotechnology

      CHO gene expression profiling in biopharmaceutical process analysis and design (pages 431–438)

      Jochen Schaub, Christoph Clemens, Peter Schorn, Tobias Hildebrandt, Werner Rust, Detlev Mennerich, Hitto Kaufmann and Torsten W. Schulz

      Article first published online: 23 SEP 2009 | DOI: 10.1002/bit.22549

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