Integrated continuous production of recombinant therapeutic proteins (pages 3018–3029)
Veena Warikoo, Rahul Godawat, Kevin Brower, Sujit Jain, Daniel Cummings, Elizabeth Simons, Timothy Johnson, Jason Walther, Marcella Yu, Benjamin Wright, Jean McLarty, Kenneth P. Karey, Chris Hwang, Weichang Zhou, Frank Riske and Konstantin Konstantinov
Version of Record online: 6 AUG 2012 | DOI: 10.1002/bit.24584
This study demonstrates the potential of integrated continuous bioprocessing as a universal platform for the manufacture of various kinds of therapeutic proteins. Integration of upstream and downstream unit operations results in the significant simplification of the entire process train due to elimination of non-value-added hold steps, dramatically shorter residence and cycle times, reduction of equipment size, and overall facility minimization.