Investigating contactless high frequency ultrasound microbeam stimulation for determination of invasion potential of breast cancer cells (pages 2697–2705)
Jae Youn Hwang, Nan Sook Lee, Changyang Lee, Kwok Ho Lam, Hyung Ham Kim, Jonghye Woo, Ming-Yi Lin, Kassandra Kisler, Hojong Choi, Qifa Zhou, Robert H. Chow and K. Kirk Shung
Version of Record online: 22 APR 2013 | DOI: 10.1002/bit.24923
The authors investigate the application ofcontactless high frequency ultrasound microbeam stimulation(HFUMS) for determining the invasion potential of breast cancer cells. Chow and coworkers found that HFUMS elicits significant calcium elevation in highly invasive breast cancer cells compared to weakly invasive breast cancer cells. Thus, this finding suggest that HFUMS may serve as a novel tool to determine the invasion potential of breast cancer cells, and with further refinement may offer a rapid test for invasiveness of tumor biopsies in situ.