Investigation of ifosfamide nephrotoxicity induced in a liver–kidney co-culture biochip (pages 597–608)
Leila Choucha-Snouber, Caroline Aninat, Laurent Grsicom, Geoffrey Madalinski, Céline Brochot, Paul Emile Poleni, Florence Razan, Christiane Guguen Guillouzo, Cécile Legallais, Anne Corlu and Eric Leclerc
Article first published online: 28 AUG 2012 | DOI: 10.1002/bit.24707
The authors develop a microfluidic biochip for liver renal tissues coculture. Liver HepaRG cells metabolize ifosfamide drugs whereas MDCK renal cells did not. Calcium release is enhanced in renal cells in the ifosfamide coculture demonstrating “systemic-like interaction” between liver and kidney cells.