A randomized clinical trial of oral ursodeoxycholic acid in obstructive jaundice
Version of Record online: 7 DEC 2005
Copyright © 1986 British Journal of Surgery Society Ltd.
British Journal of Surgery
Volume 73, Issue 8, pages 634–636, August 1986
How to Cite
Thompson, J. N., Cohen, J., Blenkharn, J. I., McConnell, J. S., Barr, J. and Blumgart, L. H. (1986), A randomized clinical trial of oral ursodeoxycholic acid in obstructive jaundice. Br J Surg, 73: 634–636. doi: 10.1002/bjs.1800730819
- Issue online: 7 DEC 2005
- Version of Record online: 7 DEC 2005
- Manuscript Received: 21 JAN 1986
- Cancer Research Campaign
- Bile salts;
- ursodeoxycholic acid;
- bile duct obstruction;
- kidney failure
Forty patients with obstructive jaundice (bilirubin > 100 μmol/l) were entered into a randomized trial of oral ursodeoxycholic acid for 48 h before surgery versus no additional therapy. Pre-operative venous and operative portal total bile salt concentrations were higher in the bile salt treated patients (P < 0.001). Portal endotoxaemia during operation was reduced in ursodeoxycholic acid treated patients (P < 0.05). There was no significant difference in systemic venous endotoxaemia, renal function or postoperative morbidity or mortality. This study suggests pre-operative oral bile salt therapy may be of no clinical benefit in patients with obstructive jaundice.