Prophylactic antibiotics in elective colorectal surgery
Article first published online: 8 DEC 2005
Copyright © 1988 British Journal of Surgery Society Ltd.
British Journal of Surgery
Volume 75, Issue 8, pages 782–785, August 1988
How to Cite
Lau, W. Y., Chu, K. W., Poon, G. P. and Ho, K. K. (1988), Prophylactic antibiotics in elective colorectal surgery. Br J Surg, 75: 782–785. doi: 10.1002/bjs.1800750819
- Issue published online: 8 DEC 2005
- Article first published online: 8 DEC 2005
- Manuscript Accepted: 10 APR 1988
- Prophylactic antibiotics;
- elective colorectal surgery
A randomized prospective study was conducted on 194 patients who underwent elective colorectal surgery for carcinoma. All patients received the same mechanical bowel preparation. In addition, patients in group A received oral neomycin and erythromycin base; patients in group B received systemic metronidazole and gentamicin, while patients in group C received both oral and systemic antibiotics. Postoperative septic complications related to colorectal surgery occurred in 27.4 per cent, 11.9 per cent and 12.3 per cent respectively in groups A, B and C (X2 = 7; P < 0.05). The incidence of sepsis in groups B and C was almost identical. Patients who received oral antibiotics alone (group A) had significantly higher risks of postoperative sepsis when compared with patients in either group B or group C (P < 0.05). As there is no additional advantage of combining oral and systemic antibiotics, we recommend systemic metronidazole and gentamicin to be used with mechanical bowel preparation in elective colorectal surgery.