Factors influencing local recurrence after excision and radiotherapy for primary breast cancer
Version of Record online: 6 DEC 2005
Copyright © 1989 British Journal of Surgery Society Ltd.
British Journal of Surgery
Volume 76, Issue 9, pages 890–894, September 1989
How to Cite
Locker, A. P., Ellis, I. O., Morgan, D. A. L., Elston, C. W., Mitchell, A. and Blamey, R. W. (1989), Factors influencing local recurrence after excision and radiotherapy for primary breast cancer. Br J Surg, 76: 890–894. doi: 10.1002/bjs.1800760906
- Issue online: 6 DEC 2005
- Version of Record online: 6 DEC 2005
- Manuscript Accepted: 11 APR 1989
- Breast cancer;
- breast conservation;
Between November 1979 and December 1986, 263 patients were treated for primary breast cancer by local excision and radiotherapy at the City Hospital, Nottingham. Local recurrence within the treated breast occurred in 56 patients (21 per cent), in 18 (6·8 per cent) of whom it was gross and uncontrollable. An analysis of clinicopathological features shows patient age, nodal status, tumour size, presence of definitive vascular invasion, adjacent ductal carcinoma in situ and grade to be predictive of local recurrence. A Cox's multivariate analysis of these factors shows the first four to be independently significant. The factors can be combined as a prognostic index which allows identification of patients at high risk of local recurrence. On the basis of these findings we have altered our selection policy for patients suitable for breast conservation.