Risk of cancer death in first-degree relatives of patients with hereditary non-polyposis cancer syndrome (Lynch type II): A study of 130 kindreds in the United Kingdom
Article first published online: 8 DEC 2005
Copyright © 1990 British Journal of Surgery Society Ltd.
British Journal of Surgery
Volume 77, Issue 12, pages 1367–1370, December 1990
How to Cite
Itoh, H., Houlston, R. S., Harocopos, C. and Slack, J. (1990), Risk of cancer death in first-degree relatives of patients with hereditary non-polyposis cancer syndrome (Lynch type II): A study of 130 kindreds in the United Kingdom. Br J Surg, 77: 1367–1370. doi: 10.1002/bjs.1800771216
- Issue published online: 8 DEC 2005
- Article first published online: 8 DEC 2005
- Manuscript Accepted: 28 JUN 1990
- Imperial Cancer Research Fund
- Hereditary non-polyposis colon cancer;
- dominant inheritance;
- relative risks
To estimate the relative risks of cancer in first-degree relatives of index patients, 130 pedigrees of dominantly inherited Lynch type II cancer family syndrome have been analysed. The risk of death from all causes was significantly increased in women over 45 years of age and the overall liability to cancer in women was greater than for men. A sevenfold increase in risk of colon cancer was found in both sexes. In female relatives the risk of breast cancer was increased fivefold and lifetime risk of breast cancer was 1 in 3.7. A screening programme based on estimated risks could be offered to first-degree relatives of index patients with Lynch type II cancer family syndrome.