Risk of cancer death in first-degree relatives of patients with hereditary non-polyposis cancer syndrome (Lynch type II): A study of 130 kindreds in the United Kingdom

Authors

  • H. Itoh,

    1. Department of Clinical Genetics, Royal Free Hospital and School of Medicine. London NW3 2QG and St. Mark's Hospital, London, UK
    Current affiliation:
    1. Department of Surgery, University of Occupational and Environmental Health, Kitakyushu 807, Japan
    Search for more papers by this author
  • R. S. Houlston,

    1. Department of Clinical Genetics, Royal Free Hospital and School of Medicine. London NW3 2QG and St. Mark's Hospital, London, UK
    Search for more papers by this author
  • C. Harocopos,

    1. Department of Clinical Genetics, Royal Free Hospital and School of Medicine. London NW3 2QG and St. Mark's Hospital, London, UK
    Search for more papers by this author
  • Dr. J. Slack

    Corresponding author
    1. Department of Clinical Genetics, Royal Free Hospital and School of Medicine. London NW3 2QG and St. Mark's Hospital, London, UK
    • Royal Free Hospital School of Medicine, London NW3 2QG, UK
    Search for more papers by this author

Abstract

To estimate the relative risks of cancer in first-degree relatives of index patients, 130 pedigrees of dominantly inherited Lynch type II cancer family syndrome have been analysed. The risk of death from all causes was significantly increased in women over 45 years of age and the overall liability to cancer in women was greater than for men. A sevenfold increase in risk of colon cancer was found in both sexes. In female relatives the risk of breast cancer was increased fivefold and lifetime risk of breast cancer was 1 in 3.7. A screening programme based on estimated risks could be offered to first-degree relatives of index patients with Lynch type II cancer family syndrome.

Ancillary