Imipenem prophylaxis in elective colorectal surgery
Article first published online: 6 DEC 2005
Copyright © 1993 British Journal of Surgery Society Ltd.
British Journal of Surgery
Volume 80, Issue 9, pages 1196–1198, September 1993
How to Cite
Karran, S. J., Sutton, G., Gartell, P., Karran, S. E., Finnis, D. and Blenkinsop, J. (1993), Imipenem prophylaxis in elective colorectal surgery. Br J Surg, 80: 1196–1198. doi: 10.1002/bjs.1800800946
- Issue published online: 6 DEC 2005
- Article first published online: 6 DEC 2005
- Manuscript Accepted: 6 JAN 1993
In a randomized controlled study of 411 patients undergoing elective colorectal surgery, the efficacy and safety of two different regimens of imipenem were compared with those of a control regimen of cefuroxime plus metronidazole. Surgical infections occurred in 92 (26·4 per cent) of 349 evaluable patients. There were no major differences between the three treatment groups. It is concluded that imipenem is as effective as cefuroxime plus metronidazole in the prevention of sepsis after elective colorectal procedures.