Value of oral antibiotic prophylaxis in colorectal surgery
Article first published online: 8 DEC 2005
Copyright © 1995 British Journal of Surgery Society Ltd.
British Journal of Surgery
Volume 82, Issue 8, pages 1046–1048, August 1995
How to Cite
McArdle, C. S., Morran, C. G., Pettit, L., Gemmell, C. G., Sleigh, J. D. and Tillotson, G. S. (1995), Value of oral antibiotic prophylaxis in colorectal surgery. Br J Surg, 82: 1046–1048. doi: 10.1002/bjs.1800820814
- Issue published online: 8 DEC 2005
- Article first published online: 8 DEC 2005
- Manuscript Accepted: 18 NOV 1994
A total of 169 patients undergoing colorectal surgery were randomly allocated to receive either gentamicin plus metronidazole or oral ciprofloxacin plus metronidazole as prophylaxis; they were also allocated to receive cover for 1 or 3 days. Twenty-eight patients (17 per cent) developed postoperative wound infections. The proportion of patients with wound infections and other infective complications was significantly less (P < 0·02) in those receiving oral ciprofloxacin. Cover for 3 days was no better than that for only 1 day. Oral ciprofloxacin for prophylaxis may offer advantages in efficacy and ease of administration compared with parenteral antibiotics.