Anatomical basis of intra-arterial chemotherapy for patients with locally advanced breast cancer
Article first published online: 6 DEC 2005
Copyright © 1996 British Journal of Surgery Society Ltd.
British Journal of Surgery
Volume 83, Issue 8, pages 1128–1130, August 1996
How to Cite
Doughty, J. C., McCarter, D. H. A., Kane, E., Reid, A. W., Cooke, T. G. and McArdle, C. S. (1996), Anatomical basis of intra-arterial chemotherapy for patients with locally advanced breast cancer. Br J Surg, 83: 1128–1130. doi: 10.1002/bjs.1800830830
- Issue published online: 6 DEC 2005
- Article first published online: 6 DEC 2005
- Manuscript Accepted: 27 NOV 1995
Twenty-eight patients with locally advanced breast cancer received four doses of regional chemotherapy via angiographically placed percutaneous catheters into the internal mammary artery (IMA) and lateral thoracic artery. Patent blue dye was injected to outline the relative contribution to perfusion of each of these vessels. The IMA was found to perfuse 67 (range 20–95) per cent of the breast and the lateral thoracic artery 15 (range 0–35) per cent. In 33 per cent of patients the lateral thoracic artery did not contribute to breast perfusion and a large area of the lateral aspect of the breast was perfused from a further branch of the subclavian or axillary artery. The blood supply to the breast is extremely variable and must be determined in each patient before delivering regional chemotherapy.