Prognostic value of monolayer culture patterning in primary cell culture of oesophageal cancer
Article first published online: 6 DEC 2005
Copyright © 1996 British Journal of Surgery Society Ltd.
British Journal of Surgery
Volume 83, Issue 8, pages 1148–1151, August 1996
How to Cite
Shimada, Y., Kanda, Y., Shibagaki, I., Kato, M., Watanabe, G., Tanaka, H., Kano, M. and Imamura, M. (1996), Prognostic value of monolayer culture patterning in primary cell culture of oesophageal cancer. Br J Surg, 83: 1148–1151. doi: 10.1002/bjs.1800830837
- Issue published online: 6 DEC 2005
- Article first published online: 6 DEC 2005
- Manuscript Accepted: 31 OCT 1995
- Japanese Ministry of Education, Science and Culture. Grant Number: 04670777
- Japanese Foundation for Multidisciplinary Treatment of Cancer
The growth of primary cell cultures of oesophageal cancer was compared with the clinical outcome of patients from whom the cancers were taken. Ninety-three patients underwent curative resection, with no operative deaths, and were divided into three groups according to the monolayer culture pattern of the primary cell culture: culture from 43 patients (46 per cent) grew no malignant cells (group 1), 21 (23 per cent) produced monolayer epithelial growth (group 2) and the rest (from 29 patients) established cell lines (group 3). The 5-year survival rate of patients in group 2 (29 per cent) and group 3 (23 per cent) was significantly lower (P < 0.005) than that of those in group 1 (51 per cent). Monolayer epithelial growth potential is a significant prognostic factor in patients with oesophageal cancer.