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Abstract

Background:

This study was designed to evaluate the prognostic value of tumour stage T2 subcategorization (T2a and T2b) in patients with gastric carcinoma.

Methods:

Clinicopathological details of a prospective series of patients who had radical resection of gastric adenocarcinoma in a single institution were analysed. Univariable and multivariable survival analyses were performed with the log rank test and Cox's model respectively.

Results:

Of 373 evaluable patients, 49 (13·1 per cent) had a T2a and 143 (38·3 per cent) a T2b tumour. At a median follow-up of 35·5 months, the 5-year overall survival rate was 73 and 31·1 per cent for patients with T2a and T2b lesions respectively (P < 0·001). On multivariable analysis, T stage remained an independent prognostic factor. Compared with T1a, the mortality risk for patients with T1b (hazard ratio (HR) 1·00; P = 0·992) and T2a (HR 0·97; P = 0·916) tumours was similar; by contrast, the risk of death associated with T2b (HR 1·81; P = 0·031) and T3 (HR 1·89; P = 0·038) lesions was significantly greater than for T1a tumours.

Conclusion:

Subclassification of T2 tumours should be undertaken routinely in order to stratify patients with gastric cancer more accurately in terms of their mortality risk. Copyright © 2009 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.