Intra-abdominal adhesions are a major source of morbidity and mortality after abdominal surgery. Although numerous antiadhesive barriers claim efficacy, none has found widespread use because of several drawbacks.
In the present study an ultrapure alginate gel consistently reduced postoperative adhesion formation in a rat model without adverse effects on wound healing. The gel is easy to apply after laparotomy and laparoscopy, and is able to achieve broad coverage of the anatomical structures of the abdomen. The alginate gel is a promising tool in the efforts to develop an optimal and low-cost adhesion-preventing barrier that is effective in all types of gastrointestinal surgery.