• Visual literacy;
  • internet resource;
  • using simulation and internet resources for teaching;
  • skill development including cognitive skills

This article describes a novel approach to teaching novice Biochemistry students visual literacy skills and understanding of some aspects of protein structure using the internet resource FoldIt and a worksheet based on selected Introductory Puzzles from this computer game. In responding to a questionnaire, students indicated that they (94%) enjoyed playing the game and furthermore, they indicated that they (100%) perceived an improvement in their understanding of protein structure as a result. Instructor observation of the students using the game together with the worksheet corroborated the results of the student perception survey. © 2012 by The International Union of Biochemistry and Molecular Biology, 41(1):56–57, 2013