Determination of dimethyl fumarate in desiccant and antimould sachets by reversed-phase liquid chromatography
Article first published online: 10 FEB 2011
Copyright © 2011 John Wiley & Sons, Ltd.
Volume 25, Issue 12, pages 1315–1318, December 2011
How to Cite
Gennari, O., Montesano, D., Salzano, A., Albrizio, S. and Grumetto, L. (2011), Determination of dimethyl fumarate in desiccant and antimould sachets by reversed-phase liquid chromatography. Biomed. Chromatogr., 25: 1315–1318. doi: 10.1002/bmc.1602
- Issue published online: 1 NOV 2011
- Article first published online: 10 FEB 2011
- Manuscript Accepted: 17 DEC 2010
- Manuscript Received: 16 DEC 2010
- dimethyl fumarate;
- desiccant antimould agent;
A method for the determination of dimethyl fumarate (DMF) in desiccant and antimould sachets, employed for protecting consumer products from humidity and mould, has been developed. The method is based on a solid–liquid extraction followed by HPLC-UV analysis. The method was validated with respect to recovery, linearity, limits of detection and quantitation and precision. The recovery was 98%. The correlation coefficient value (r) was equal to 0.94. Both intra- and inter-day precisions were studied at several concentration levels, being satisfactory in all cases (RSD < 5). Limits of detection and quantification values were in the low microgram per gram level, thus allowing the determination of DMF at concentrations below the limit established (0.1 mg/kg) by the recent EU Directive (Decision 2009/251/EC). The proposed procedure was applied for the determination of the target compound in 41 desiccant and antimould samples. DMF was detected in 39.0% of samples and its content in many samples exceeded the legal limits. The results of our analysis highlight the high risk of exposure to this powerful allergic sensitizer for consumers. Copyright © 2011 John Wiley & Sons, Ltd.