Detection of perfluorocarbons in blood by headspace solid-phase microextraction combined with gas chromatography/mass spectrometry

Authors


Abstract

A new method of detection of perfluorocarbon molecules (PFCs) in blood sample has been established. After an extraction and pre-concentration step performed by headspace solid-phase microextraction (HS-SPME), the PFCs are detected by gas chromatography-mass spectrometry (GC/MS) with an ion trap mass spectrometer in MS and MS/MS modes. The influence of different parameters on the SPME process is discussed. The limit of detection and the linearity of the procedure have been determined for two PFCs. Copyright © 2001 John Wiley & Sons, Ltd.

Abbreviations used:
EI

electron impact

EPO

erythropoietin

FDC

F-decaline

HS-SPME

headspace solid-phase extraction

IOC

International Olympic Committee

LOD

Limit of detection

PDMS

polydimethylsiloxane

PFCs

perfluorocarbon molecules

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