Studies on anabolic steroids. The mass spectra of 17α-methyl-17β-hydroxy-1,4-androstadien-3-one (dianabol) and its metabolites
Article first published online: 11 APR 2005
Copyright © 1980 John Wiley & Sons, Ltd.
Biological Mass Spectrometry
Volume 7, Issue 10, pages 437–445, October 1980
How to Cite
Dürbeck, H. W. and Büker, I. (1980), Studies on anabolic steroids. The mass spectra of 17α-methyl-17β-hydroxy-1,4-androstadien-3-one (dianabol) and its metabolites. Biol. Mass Spectrom., 7: 437–445. doi: 10.1002/bms.1200071007
- Issue published online: 11 APR 2005
- Article first published online: 11 APR 2005
- Manuscript Received: 2 JUN 1980
The metabolism of 17α-methyl-17β-hydroxy-1,4-androstadien-3-one (dianabol) in human adults has been studied in detail by computer aided capillary gas chromatography mass spectrometry. After oral administration to man six metabolites were determined in the free fraction of the urine samples, the structures of which have been identified as 17-epidianabol, three isomers of 6-hydroxydianabol, 17α-methyl-17β-hydroxy-1,4,6-androstatrien-3-one (Δ6-dianabol) and 18-nor-17,17-dimethyl-1,4,13(14)-androstatrien-3-one, respectively. In agreement with previous observations no measurable amounts of the administered drug itself could be detected in any of the urine samples investigated. The mass spectra of all metabolites and the main fragmentation processes are discussed in detail.