Matrix enhanced laser desorption in mass spectrometry and tandem mass spectrometry
Article first published online: 11 APR 2005
Copyright © 1985 John Wiley & Sons, Ltd.
Biological Mass Spectrometry
Volume 12, Issue 4, pages 159–162, April 1985
How to Cite
Wright, L. G., Cooks, R. G. and Wood, K. V. (1985), Matrix enhanced laser desorption in mass spectrometry and tandem mass spectrometry. Biol. Mass Spectrom., 12: 159–162. doi: 10.1002/bms.1200120404
- Issue published online: 11 APR 2005
- Article first published online: 11 APR 2005
- Manuscript Accepted: 19 OCT 1984
- Manuscript Received: 13 AUG 1984
When sampled by laser irradiation from a suitable matrix, cationized sugars can be desorbed in far higher yields for longer periods than in experiments which do not employ a matrix. Daughter spectra reveal that Li+ reacts differently from the other alkali ions in that it can catalyse ring opening; collision-induced dissociation then causes successive CC cleavage reactions. Selectivity is also exhibited by the substrate; some isomers yield much more intense ion currents with the alkali metals than do others. These findings should contribute to a wider use of laser desorption, including selective examination of mixtures for particular types of compounds, as well as detailed structural studies on individual substances.