A revision of the metabolic disposition of amantadine
Article first published online: 11 APR 2005
Copyright © 1985 John Wiley & Sons, Ltd.
Biological Mass Spectrometry
Volume 12, Issue 9, pages 499–501, September 1985
How to Cite
Köppel, C. and Tenczer, J. (1985), A revision of the metabolic disposition of amantadine. Biol. Mass Spectrom., 12: 499–501. doi: 10.1002/bms.1200120910
- Issue published online: 11 APR 2005
- Article first published online: 11 APR 2005
- Manuscript Accepted: 25 JUL 1984
- Manuscript Received: 18 MAY 1984
Amantadine is one of the most commonly used drugs for the control of tremor in Parkinson's disease. Additionally, it has an antiviral action in the prevention of type A influenza. It has been previously reported that amantadine is nearly completely eliminated in the urine. No metabolites have been detected. Surprisingly, in a case of amantadine overdose, several metabolites could be identified by gas chromatography/mass spectrometry. This finding prompted us to re-investigate the metabolism of amantadine under a therapeutic dosing regimen. The bulk of the dose was eliminated unchanged. However, eight metabolites could be identified. Besides N-acetylation which is the major metabolic pathway, several rather unusual metabolic pathways were observed: N-methylation, formation of Schiff bases and N-formiates. No metabolites with a hydroxylated adamantane ring system could be detected.