Article

Keto acids in tissues and biological fluids: O-t-butyldimethylsilyl quinoxalinols as derivatives for sensitive gas chromatographic/mass spectrometric determination

  1. U. Langenbeck1,*,
  2. H. Luthe2,
  3. Gritta Schaper2,†

Article first published online: 11 APR 2005

DOI: 10.1002/bms.1200120912

Issue

Biological Mass Spectrometry

Biological Mass Spectrometry

Volume 12, Issue 9, pages 507–509, September 1985

Additional Information

How to Cite

Langenbeck, U., Luthe, H. and Schaper, G. (1985), Keto acids in tissues and biological fluids: O-t-butyldimethylsilyl quinoxalinols as derivatives for sensitive gas chromatographic/mass spectrometric determination. Biol. Mass Spectrom., 12: 507–509. doi: 10.1002/bms.1200120912

Author Information

  1. 1

    Institute of Human Genetics, University of Göttingen, D-3400 Göttingen, FRG

  2. 2

    Dept of Clinical Chemistry, University of Göttingen, D-3400 Göttingen, FRG

  1. †

    In partial fulfillment of Ph.D. requirements.

*Institute of Human Genetics, Nikolausberger Weg 5a, D-3400 Göttingen, FRG

  1. †

    In partial fulfillment of Ph.D. requirements.

Publication History

  1. Issue published online: 11 APR 2005
  2. Article first published online: 11 APR 2005
  3. Manuscript Accepted: 2 AUG 1984
  4. Manuscript Received: 25 JUN 1984

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Abstract

Quinoxalinol t-butyldimethylsilyl ethers were prepared from three branched-chain and from two aliphatic unbranched 2-keto acids. The electron impact (EI) mass spectra display pronounced [M −57]+ ions. With 39–51% of total ion current contained within them, sensitivity is greater than on chemical ionization (CI) mass spectrometry of O-trimethylsilyl derivatives. Mass spectra and chromatographic behaviour of these novel keto acid derivatives are discussed and preliminary quantitative data from rat muscle are given.

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