Simultaneous determination of captopril and S-benzoyl captopril in human blood by capillary gas chromatography–mass selective detection

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Abstract

Using a new table-top electron-impact mass selective detector, interfaced with a narrow bore, fused silica capillary gas chromatograph, a method has been developed for the simultaneous determination of captopril and S-benzoyl captopril. With a capillary column the two components could be chromatographically resolved, thus permitting the use of electron-impact ionization for quantitative measurements.

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