Sensory deprivation during early development causes an increased exploratory behavior in a whisker-dependent decision task
Article first published online: 29 NOV 2012
© 2012 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
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Brain and Behavior
Volume 3, Issue 1, pages 24–34, January 2013
How to Cite
Brain and Behavior 2013; 3(1):24–34.
- Issue published online: 9 JAN 2013
- Article first published online: 29 NOV 2012
- Manuscript Accepted: 9 OCT 2012
- Manuscript Revised: 19 SEP 2012
- Manuscript Received: 20 JUN 2012
- Barrel cortex;
- sensory deprivation;
- whisker tracking
Stimulation of sensory pathways is important for the normal development of cortical sensory areas, and impairments in the normal development can have long-lasting effect on animal's behavior. In particular, disturbances that occur early in development can cause permanent changes in brain structure and function. The behavioral effect of early sensory deprivation was studied in the mouse whisker system using a protocol to induce a 1-week sensory deprivation immediately after birth. Only two rows of whiskers were spared (C and D rows), and the rest were deprived, to create a situation where an unbalanced sensory input, rather than a complete loss of input, causes a reorganization of the sensory map. Sensory deprivation increased the barrel size ratio of the spared CD rows compared with the deprived AB rows; thus, the map reorganization is likely due, at least in part, to a rewiring of thalamocortical projections. The behavioral effect of such a map reorganization was investigated in the gap-crossing task, where the animals used a whisker that was spared during the sensory deprivation. Animals that had been sensory deprived performed equally well with the control animals in the gap-crossing task, but were more active in exploring the gap area and consequently made more approaches to the gap – approaches that on average were of shorter duration. A restricted sensory deprivation of only some whiskers, although it does not seem to affect the overall performance of the animals, does have an effect on their behavioral strategy on executing the gap-crossing task.