Dopamine-transporter levels drive striatal responses to apomorphine in Parkinson's disease
Version of Record online: 22 MAR 2013
© 2013 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
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Brain and Behavior
Volume 3, Issue 3, pages 249–262, May 2013
How to Cite
Brain and Behavior 2013; 3(3):249–262.
- Issue online: 13 MAY 2013
- Version of Record online: 22 MAR 2013
- Manuscript Accepted: 30 NOV 2012
- Manuscript Revised: 15 NOV 2012
- Manuscript Received: 24 AUG 2012
- Consiglio Nazionale delle Ricerche
|brb3115-sup-0001-FigureS1.tif||image/tif||1003K||Figure S1. Nonlinear interactions between treatment (Off-, On-apomorphine), prefrontal cortex (PFC) response during low-, medium-, high-load working memory, and dopamine transporter (DAT)-BPND values in patients with Parkinson's disease (PD). In PD-Off, the relation between the PFC BOLD activity and DAT-BPND values follows a U-shaped model; in contrast, the same relation follows an inverted-U shape model in PD-On. The color bars represent T statistics. For display purposes, maps are thresholded at P < 0.005, uncorrected, but results are significant at P < 0.05, familywise error (FWE), small volume correction (svc). Coordinates (x, y, and z) are in the Montreal Neurological Institute (MNI) space. BOLD, blood oxygenated level dependent.|
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