brb3115-sup-0001-FigureS1.tifimage/tif1003KFigure S1. Nonlinear interactions between treatment (Off-, On-apomorphine), prefrontal cortex (PFC) response during low-, medium-, high-load working memory, and dopamine transporter (DAT)-BPND values in patients with Parkinson's disease (PD). In PD-Off, the relation between the PFC BOLD activity and DAT-BPND values follows a U-shaped model; in contrast, the same relation follows an inverted-U shape model in PD-On. The color bars represent T statistics. For display purposes, maps are thresholded at P < 0.005, uncorrected, but results are significant at P < 0.05, familywise error (FWE), small volume correction (svc). Coordinates (x, y, and z) are in the Montreal Neurological Institute (MNI) space. BOLD, blood oxygenated level dependent.

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