Social behavior is perturbed in mice after exposure to bisphenol A: a novel assessment employing an IntelliCage
Article first published online: 20 FEB 2013
© 2013 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
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Brain and Behavior
Volume 3, Issue 3, pages 223–228, May 2013
How to Cite
Brain and Behavior 2013; 3(3):223–228.
- Issue published online: 13 MAY 2013
- Article first published online: 20 FEB 2013
- Manuscript Accepted: 18 JAN 2013
- Manuscript Revised: 10 JAN 2013
- Manuscript Received: 2 OCT 2012
- JSPS-KAKENHI, Grants-in-Aid. Grant Number: 20310036
- Environment Research and Technology Development Fund of the Ministry of the Environment. Grant Number: S2-12
- Japanese National Government
- Bisphenol A;
- social behavior
In order to investigate whether or not prenatal and lactational exposure to bisphenol A (BPA) affects social behavior in mice, pregnant mice were exposed to 500 μg/kg of BPA daily from embryonic day 0 (E0) until postnatal day 21 (P21). The behavior of offspring was monitored at 11–13 and 13–15 weeks of age using an automated behavior assessment system (IntelliCage). Groups of eight mice were tasked with a nose poke, which enabled the mice to open a door to drink bottled water at the corner of their cage. BPA-exposed females visited the corner without drinking behavior during the light cycle less frequently than control female mice did. BPA-exposed males stayed at the corner for longer periods of time and showed a significantly stronger bias in the visit with drinking. In addition, the BPA-exposed males showed a shorter time interval before they visited the corner after preceding animals had visited it, compared with the control males. These findings suggest that prenatal and lactational BPA exposure might affect murine motivational behavior in a social setting differently in males and females.