Anxiety type modulates immediate versus delayed engagement of attention-related brain regions

Authors


Correspondence

Jeffrey M. Spielberg, Institute of Personality and Social Research, University of California, Berkeley, 4135 Tolman Hall, MC 5050, Berkeley, CA 94720. Tel: (217) 781-4001; Fax: (510) 643-9334; E-mail: jspielb2@gmail.com

Abstract

Background

Habituation of the fear response, critical for the treatment of anxiety, is inconsistently observed during exposure to threatening stimuli. One potential explanation for this inconsistency is differential attentional engagement with negatively valenced stimuli as a function of anxiety type.

Methods

The present study tested this hypothesis by examining patterns of neural habituation associated with anxious arousal, characterized by panic symptoms and immediate engagement with negatively valenced stimuli, versus anxious apprehension, characterized by engagement in worry to distract from negatively valenced stimuli.

Results

As predicted, the two anxiety types evidenced distinct patterns of attentional engagement. Anxious arousal was associated with immediate activation in attention-related brain regions that habituated over time, whereas anxious apprehension was associated with delayed activation in attention-related brain regions that occurred only after habituation in a worry-related brain region.

Conclusions

Results further elucidate mechanisms involved in attention to negatively valenced stimuli and indicate that anxiety is a heterogeneous construct with regard to attention to such stimuli.

Ancillary