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Brain and Behavior

Cover image for Vol. 2 Issue 4

July 2012

Volume 2, Issue 4

Pages i–i, 357–523

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Original Research
    4. Reviews
    1. You have full text access to this OnlineOpen article
      Issue Information (page i)

      Article first published online: 13 JUL 2012 | DOI: 10.1002/brb3.79

  2. Original Research

    1. Top of page
    2. Issue Information
    3. Original Research
    4. Reviews
    1. You have full text access to this OnlineOpen article
      Mood symptoms contribute to working memory decrement in active-duty soldiers being treated for posttraumatic stress disorder (pages 357–364)

      Michael N. Dretsch, Kenneth J. Thiel, Jeremy R. Athy, Clinton R. Irvin, Bess Sirmon-Fjordbak and Anthony Salvatore

      Article first published online: 4 MAY 2012 | DOI: 10.1002/brb3.53

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      Impaired working memory functioning in soldiers with posttraumatic stress disorder. Mood symptoms contribute to working memory decrement.

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      Hypothalamic expression of Peg3 gene is associated with maternal care differences between SM/J and LG/J mouse strains (pages 365–376)

      Silvana Chiavegatto, Bruno Sauce, Guilherme Ambar, James M. Cheverud and Andrea C. Peripato

      Article first published online: 21 MAY 2012 | DOI: 10.1002/brb3.58

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      Maternal care is essential in mammals, and the environment provided by mothers may directly influence the viability of newborns and emotional behavior later in life. We investigated three candidate genes Oxt, FosB and Peg3 in LG/J and SM/J postpartum females contrasting some maternal care features that are impaired in the first ones. We observed a copy number variation in a stretch of 10 amino acids in the Peg3 gene with a higher number of repeats in LG/J females which, along with its lower levels of expression on the hypothalamus when compared to SM/J females, suggests its participation in maternal care variation between LG/J and SM/J mouse strains.

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      Use of cranial CT to identify a new infarct in patients with a transient ischemic attack (pages 377–381)

      Mohamed Al-Khaled, Christine Matthis, Thomas F. Münte and Jürgen Eggers

      Article first published online: 21 MAY 2012 | DOI: 10.1002/brb3.59

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      Use of head CT to detect new infarction in patients with TIA and clinical predictors of CT finding in patients with TIA.

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      The relationship between nerve conduction velocity and fiber morphology during peripheral nerve regeneration (pages 382–390)

      Masayoshi Ikeda and Yoshinori Oka

      Article first published online: 4 JUN 2012 | DOI: 10.1002/brb3.61

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      The regression relation between fiber diameter and internodal length was not a sensitive index of recovery. MCV and mean fiber diameter were the most sensitive indices of functional recovery during sciatic nerve regeneration.

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      Pharmacological evidence that D-aspartate activates a current distinct from ionotropic glutamate receptor currents in Aplysia californica (pages 391–401)

      Stephen L. Carlson, Andrew T. Kempsell and Lynne A. Fieber

      Article first published online: 4 JUN 2012 | DOI: 10.1002/brb3.60

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      D-Aspartate (D-Asp) activates a Na+ and K+ current of unknown identity independent of L-glutamate (L-Glu) in neurons of Aplysia californica. Portions of D-Asp currents were blocked by L-Glu antagonists including kynurenate and APV, but L-Glu currents were unaffected by APV, and showed greater block by kynurenate, suggesting that D-Asp and L-Glu may act at different sites. The mixed pharmacological results as well as an asymmetrical desensitization by D-Asp of L-Glu currents suggest that D-Asp channels in Aplysia are not uniformly characteristic of any known agonist-associated channel type.

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      The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats (pages 402–414)

      Parizad Avari, Wenlong Huang, Sharon Averill, Bartomeu Colom, Beat A. Imhof, Sussan Nourshargh and John V. Priestley

      Article first published online: 7 JUN 2012 | DOI: 10.1002/brb3.63

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      We have examined the expression of JAM-C, a junctional adhesion molecule, in the rat sciatic nerve after crush injury. Expression, which was confined to paranodes and Schwann cell incisures, was downregulated after injury and re-expressed during axon regeneration. The time course of expression indicates possible roles for JAM-C in remyelination and node formation.

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      Impaired social decision making in patients with major depressive disorder (pages 415–423)

      Hui-jun Zhang, Delin Sun and Tatia M. C. Lee

      Article first published online: 13 JUN 2012 | DOI: 10.1002/brb3.62

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      Research on how depression influences social decision making has been scarce. Findings of this study clearly illustrate that people with depression demonstrated a pattern of social decision making different from that of the healthy counterparts. These results contribute to furthering our understanding of the specific pattern of social behavioral changes associated with depression.

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      A novel Drosophila SOD2 mutant demonstrates a role for mitochondrial ROS in neurodevelopment and disease (pages 424–434)

      Alicia M. Celotto, Zhaohui Liu, Andrew P. VanDemark and Michael J. Palladino

      Article first published online: 25 JUN 2012 | DOI: 10.1002/brb3.73

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      This article investigates the basis of neurodevelopmental defects resulting from SOD2 loss-of-function. We discovered an increase in neuronal mistargeting that could underlie the observed aberrant neurodevelopment and brain morphology defects. This novel allele, SOD2bewildered, provides a unique opportunity to study the effects of increased mitochondrial ROS on neural development, axonal targeting, and neural cell degeneration in vivo.

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      Prevalence, laterality, and comorbidity of hippocampal sclerosis in an autopsy sample (pages 435–442)

      Chris Zarow, Michael W. Weiner, William G. Ellis and Helena Chang Chui

      Article first published online: 26 JUN 2012 | DOI: 10.1002/brb3.66

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      In this study we found 31 cases of hippocampal sclerosis (HS) in a sample of 130 consecutive autopsy cases from the Ischemic Vascular Dementia Program Project. Because all cases were reviewed bilaterally we found that HS could be either unilateral or bilateral. While roughly half of all cases were bilateral, more than half of unilateral cases were left-only. While HS can be found as the sole pathological finding it is more frequently found in the context of other neurodegenerative diseases. Perhaps because of this, HS in late life is never diagnosed clinically.

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      A promising randomized trial of a new therapy for obsessive–compulsive disorder (pages 443–454)

      Xian-Zhang Hu, You-Sheng Wen, Jian-Dong Ma, Dong-Ming Han, Yu-Xia Li and Shu-Fan Wang

      Article first published online: 26 JUN 2012 | DOI: 10.1002/brb3.67

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      More efficacious therapeutic approach for obsessive–compulsive disorder (OCD) is strongly needed since there are limitations in both pharmacotherapy and psychotherapy. A novel psychotherapy, cognitive–coping therapy, has been established and our data suggest that it is an efficacious approach for OCD treatment and might be a potential complementary treatment of OCD for long term with higher response and remission rate, higher compliance, and lower rate of relapse.

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      Maternal separation is associated with strain-specific responses to stress and epigenetic alterations to Nr3c1, Avp, and Nr4a1 in mouse (pages 455–467)

      R. L. Kember, E. L. Dempster, T. H. A. Lee, L. C. Schalkwyk, J. Mill and C. Fernandes

      Article first published online: 29 JUN 2012 | DOI: 10.1002/brb3.69

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      Using a maternal separation paradigm, we investigated phenotypic and epigenetic changes following early life stress in two inbred strains of mice, C57BL/6J and DBA/2J. We found an increase in the corticosterone response to stress in male, C57BL/6J mice that had undergone maternal separation, and early life stress induced a number of mild but significant behavioral changes, many of which were dependent on genetic background.

  3. Reviews

    1. Top of page
    2. Issue Information
    3. Original Research
    4. Reviews
    1. You have full text access to this OnlineOpen article
      Human neuronal uncoupling proteins 4 and 5 (UCP4 and UCP5): structural properties, regulation, and physiological role in protection against oxidative stress and mitochondrial dysfunction (pages 468–478)

      David B. Ramsden, Philip W.-L. Ho, Jessica W.-M. Ho, Hui-Fang Liu, Danny H.-F. So, Ho-Man Tse, Koon-Ho Chan and Shu-Leong Ho

      Article first published online: 11 JUN 2012 | DOI: 10.1002/brb3.55

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      In this review, we discussed the structure and function of neuronal mitochondrial uncoupling proteins (UCP) 4 and 5 and factors influencing their expression.

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      The use of P300-based BCIs in amyotrophic lateral sclerosis: from augmentative and alternative communication to cognitive assessment (pages 479–498)

      Pietro Cipresso, Laura Carelli, Federica Solca, Daniela Meazzi, Paolo Meriggi, Barbara Poletti, Dorothée Lulé, Albert C. Ludolph, Vincenzo Silani and Giuseppe Riva

      Article first published online: 19 JUN 2012 | DOI: 10.1002/brb3.57

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      The use of Augmentative and Alternative Communication (AAC) tools in patients with amyotrophic lateral sclerosis (ALS), as effective means to compensate for the progressive loss of verbal and gestural communication, has been deeply investigated in the recent literature. The development of advanced AAC systems, such as brain-computer interface (BCI) devices, allowed to bypass the important motor difficulties present in ALS patients. More, BCIs could offer a new possibility to administer cognitive tasks without the need of verbal or motor responses, as highlighted by preliminary studies in this field. In this review, we outline the essential features of BCIs systems, considering advantages and challenges of these tools with regard to ALS patients and the main applications developed in this field.

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      Substrates of neuropsychological functioning in stimulant dependence: a review of functional neuroimaging research (pages 499–523)

      Cleo L. Crunelle, Dick J. Veltman, Jan Booij, Katelijne van Emmerik – van Oortmerssen and Wim van den Brink

      Article first published online: 26 JUN 2012 | DOI: 10.1002/brb3.65

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      Stimulant dependence is associated with neuropsychological impairments. We summarize and integrate the existing neuroimaging literature on the neural substrates of neuropsychological (dys)function in stimulant dependence, including cocaine, (meth-)amphetamine, ecstasy and nicotine dependence, and excessive caffeine use, comparing stimulant abusers to non-drug using healthy controls.

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