The use of P300-based BCIs in amyotrophic lateral sclerosis: from augmentative and alternative communication to cognitive assessment (pages 479–498)
Pietro Cipresso, Laura Carelli, Federica Solca, Daniela Meazzi, Paolo Meriggi, Barbara Poletti, Dorothée Lulé, Albert C. Ludolph, Vincenzo Silani and Giuseppe Riva
Article first published online: 19 JUN 2012 | DOI: 10.1002/brb3.57
The use of Augmentative and Alternative Communication (AAC) tools in patients with amyotrophic lateral sclerosis (ALS), as effective means to compensate for the progressive loss of verbal and gestural communication, has been deeply investigated in the recent literature. The development of advanced AAC systems, such as brain-computer interface (BCI) devices, allowed to bypass the important motor difficulties present in ALS patients. More, BCIs could offer a new possibility to administer cognitive tasks without the need of verbal or motor responses, as highlighted by preliminary studies in this field. In this review, we outline the essential features of BCIs systems, considering advantages and challenges of these tools with regard to ALS patients and the main applications developed in this field.