Dopamine-transporter levels drive striatal responses to apomorphine in Parkinson's disease (pages 249–262)
Luca Passamonti, Maria Salsone, Nicola Toschi, Antonio Cerasa, Marco Giannelli, Carmelina Chiriaco, Giuseppe Lucio Cascini, Francesco Fera and Aldo Quattrone
Version of Record online: 22 MAR 2013 | DOI: 10.1002/brb3.115
We studied how dopamine-transporter (DAT) levels influenced brain responses to apomorphine, a potent dopamine agonist, in Parkinson's disease (PD) patients executing a working-memory task. We found an inverted-U-shaped relation between DAT levels and striatal response to apomorphine and interpreted these findings as reflecting changes in striatal D2-receptor sensitivity. In future, multimodal brain markers may be useful for personalizing drug therapy in PD.