Genome-wide polygenic scoring for a 14-year long-term average depression phenotype
Article first published online: 12 FEB 2014
© 2014 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
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Brain and Behavior
Volume 4, Issue 2, pages 298–311, March 2014
How to Cite
Brain and Behavior 2014; 4(2): 298–311
- Issue published online: 12 MAR 2014
- Article first published online: 12 FEB 2014
- Manuscript Accepted: 24 NOV 2013
- Manuscript Revised: 30 OCT 2013
- Manuscript Received: 11 MAR 2013
- National Institutes of Health/National Institute of Mental Health. Grant Number: MH092707-01
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Data S1. Candidate Gene Polygenic Scoring in NHS (NHS-Candidate-PS)
Figure S1. Quantile plot of polygenic scores (PS) on 14-year long-term average composite depression phenotype.
Table S1. Depression-related measures collected in the Nurses' Health Study.
Table S2. Study-specific genotyping, imputation, and statistical analysis.
Table S3. Sample quality control.
Table S4. Percentage of variance* in depression phenotypes explained by variables associated with depression in the NHS full cohort, restricting to women with nonmissing 2004 CESD-10 and 14-year long-term average depression scores (N = 73,897).
Table S5. Meta-analysis of percentage of variance explained in depression phenotype in NHS by the candidate gene polygenic scores in the leave-one-substudy-out analysis (N = 6989).
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