Executive deficits detected in mild Alzheimer's disease using the antisaccade task
Article first published online: 7 DEC 2011
©2011 The Authors. Brain and Behavior published by Blackwell Publishing Ltd.
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Brain and Behavior
Volume 2, Issue 1, pages 15–21, January 2012
How to Cite
Kaufman, L. D., Pratt, J., Levine, B. and Black, S. E. (2012), Executive deficits detected in mild Alzheimer's disease using the antisaccade task. Brain and Behavior, 2: 15–21. doi: 10.1002/brb3.28
- Issue published online: 30 JAN 2012
- Article first published online: 7 DEC 2011
- Received: 03 July 2011; Revised: 23 October 2011; Accepted: 07 November 2011
- Alzheimer's disease;
- executive control;
The antisaccade task, a hands- and language-free metric, may provide a functional index of the dorsolateral prefrontal cortex (DLPFC), a region damaged in the later stages of Alzheimer's disease (AD). Our objective was to determine if patients with mild AD made more errors relative to age-matched controls. Thirty patients with mild AD (Mini Mental Status Exam [MMSE] ≥ 17) and 31 age-matched controls completed a laptop version of the prosaccades and antisaccades tasks. Patients with AD made more antisaccade errors, and corrected fewer errors, than age-matched controls. Error rates, corrected or uncorrected, were not correlated with AD MMSE or Dementia Rating Scale scores. Our findings indicate that antisaccade impairments exist in mild AD, suggesting clinically detectable DLPFC pathology may be present earlier than suggested by previous studies.