Eye-of-the-Tiger sign is not Pathognomonic of Pantothenate Kinase-Associated Neurodegeneration in Adult Cases
Article first published online: 30 MAY 2011
©2011 The Authors. Brain and Behavior published by Blackwell Publishing Ltd.
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Brain and Behavior
Volume 1, Issue 1, pages 55–56, September 2011
How to Cite
Chang, C.-L. and Lin, C.-M. (2011), Eye-of-the-Tiger sign is not Pathognomonic of Pantothenate Kinase-Associated Neurodegeneration in Adult Cases. Brain and Behavior, 1: 55–56. doi: 10.1002/brb3.8
- Issue published online: 29 SEP 2011
- Article first published online: 30 MAY 2011
- Received: 25 April 2011; Revised: 03 May 2011; Accepted: 08 May 2011.
- Neurodegeneration with brain iron accumulation;
- pantothenate kinase-associated neurodegeneration;
- pantothenate kinase 2;
- eye-of-the-tiger sign;
- Hallervorden-Spatz syndrome
An eye-of-the-tiger sign is previously known to have one-to-one correlation with pantothenate kinase-associated neurodegeneration (PKAN). Reviewing the literature on this subject, the correlation between eye-of-the-tiger sign and PKAN seems to show an interesting hypothesis that differs from conventional conclusion. We analyze the published papers in an attempt to reflect this trend and illustrate our points with findings in a 39-year-old man. His brain magnetic resonance imaging study shows typical eye-of-the-tiger sign suggestive of PKAN. Genetic analyses revealed no mutations in pantothenate kinase 2.