Comparison of weight changes following unilateral and staged bilateral STN DBS for advanced PD
Article first published online: 20 JUN 2011
©2011 The Authors. Brain and Behavior published by Blackwell Publishing Ltd.
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Brain and Behavior
Volume 1, Issue 1, pages 12–18, September 2011
How to Cite
Lee, E. M., Kurundkar, A., Cutter, G. R., Huang, H., Guthrie, B. L., Watts, R. L. and Walker, H. C. (2011), Comparison of weight changes following unilateral and staged bilateral STN DBS for advanced PD. Brain and Behavior, 1: 12–18. doi: 10.1002/brb3.9
- Issue published online: 29 SEP 2011
- Article first published online: 20 JUN 2011
- Received: 03 April 2011; Revised: 11 May 2011; Accepted: 12 May 2011.
- deep brain stimulation;
- Parkinson's disease;
Unilateral and bilateral subthalamic nucleus deep brain stimulation (STN DBS) in Parkinson's disease (PD) result in weight gain in the initial postoperative months, but little is known about the changes in weight following unilateral and staged bilateral STN DBS over longer time intervals. A case–control comparison evaluated weight changes over 2 years in 43 consecutive unilateral STN DBS patients, among whom 25 elected to undergo staged bilateral STN DBS, and 21 age-matched and disease severity matched PD controls without DBS. Regression analyses incorporating age, gender, and baseline weight in case or control were conducted to assess weight changes 2 years after the initial unilateral surgery. Unilateral STN DBS and staged bilateral STN DBS patients gained 3.9 ± 2.0 kg and 5.6 ± 2.1 kg versus their preoperative baseline weight (P < 0.001, respectively) while PD controls without DBS lost 0.8 ± 1.1 kg. Although bilateral STN DBS patients gained 1.7 kg more than unilateral STN DBS patients at 2 years, this difference was not statistically significant (P= 0.885). Although there was a trend toward greater weight gain in staged bilateral STN DBS patients versus unilateral patients, we found no evidence for an equivalent or synergistic increase in body weight following placement of the second DBS electrode.