The authors thank the National Science Council, Taiwan, for financial support for this research under contract no. NSC 99-2112-M-017-001-MY3 and no. NSC 99-2511-S-017-004-MY3.
Age- and disease-related features of task-related brain oscillations by using mutual information
Article first published online: 23 SEP 2012
© 2012 The Authors. Brain and Behavior published by Wiley Periodicals, Inc.
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Brain and Behavior
Volume 2, Issue 6, pages 754–762, November 2012
How to Cite
Brain and Behavior 2012; 2(6): 754–762
- Issue published online: 9 NOV 2012
- Article first published online: 23 SEP 2012
- Manuscript Accepted: 27 AUG 2012
- Manuscript Revised: 15 AUG 2012
- Manuscript Received: 21 JAN 2012
- National Science Council. Grant Numbers: NSC 99-2112-M-017-001-MY3, NSC 99-2511-S-017-004-MY3
- cross-mutual information;
- mild cognitive impairment;
- theta band
The aim of this study was to investigate changes in task-related brain oscillations and corticocortical connections in patients with mild cognitive impairment (MCI) and those with normal aging using cross-mutual information (CMI) analysis. We hypothesized that task-related brain oscillations and corticocortical connections were affected by age- and disease-related changes, which could be reflected in the CMI analysis. Electroencephalogram (EEG) recordings were measured in 16 MCI patients, 15 healthy age-matched controls, and 16 healthy younger individuals. The frequencies and interhemispheric CMI data were estimated in all groups. The specific EEG rhythms measured were delta (δ), theta (θ), alpha (α), beta (β), and gamma (γ) bands. Significant differences in δ, θ, α, and β bands were observed between the younger and elderly groups. However, only the θ band was significantly different between the elderly and MCI groups. Moreover, this study used EEG recordings to investigate age- and disease-related changes in the corticocortical connections of the brain. This study proves that the θ-band frequency of the connection between the parietal and occipital lobes for the age- and disease-related changes can be depicted using the CMI analysis.