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Abstract

The synthesis of bradykinin analogues is described in which the Gly4-Phe5, Phe5-Ser6 or the Pro7-Phe8 peptide bond has been replaced by a trans carbon-carbon double bond or by a “reduced” peptide bond. Some of the analogues display high potency and prolonged activity in the rat blood pressure test, indicating increased metabolic stability. A clear selectivity is obtained towards the myotropic effect in the guinea pig ileum.