Formulation and Engineering of Biomaterials

Synthesis, biophysical properties, and oxygenation potential of variable molecular weight glutaraldehyde-polymerized bovine hemoglobins with low and high oxygen affinity†

  1. Yipin Zhou1,
  2. Yiping Jia2,
  3. Paul W. Buehler2,
  4. Guo Chen1,
  5. Pedro Cabrales3,
  6. Andre F. Palmer1,*

Article first published online: 16 MAY 2011

DOI: 10.1002/btpr.624

Issue

Biotechnology Progress

Biotechnology Progress

Volume 27, Issue 4, pages 1172–1184, July/August 2011

Additional Information

How to Cite

Zhou, Y., Jia, Y., Buehler, P. W., Chen, G., Cabrales, P. and Palmer, A. F. (2011), Synthesis, biophysical properties, and oxygenation potential of variable molecular weight glutaraldehyde-polymerized bovine hemoglobins with low and high oxygen affinity. Biotechnol Progress, 27: 1172–1184. doi: 10.1002/btpr.624

Author Information

  1. 1

    William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210

  2. 2

    Laboratory of Biochemistry and Vascular Biology, Division of Hematology, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bethesda, MD 20892

  3. 3

    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093

*William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH 43210

  1. †

    The findings and conclusions in this article have not been formally disseminated by the Food and Drug Administration and should not be construed to represent any agency determination or policy.

Publication History

  1. Issue published online: 3 AUG 2011
  2. Article first published online: 16 MAY 2011
  3. Accepted manuscript online: 20 APR 2011 12:39PM EST
  4. Manuscript Revised: 2 MAR 2011
  5. Manuscript Received: 2 DEC 2010

Funded by

  • National Institutes of Health. Grant Numbers: R01HL078840, R01DK070862

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article (HTML) Get PDF (1178K)

Cited in:

CrossRef

This article has been cited by:

  1. 1
    J. H. Baek, Y. Zhou, D. R. Harris, D. J. Schaer, A. F. Palmer, P. W. Buehler, Down Selection of Polymerized Bovine Hemoglobins for Use as Oxygen Releasing Therapeutics in a Guinea Pig Model, Toxicological Sciences, 2012, 127, 2, 567

    CrossRef

  2. 2
    Yipin Zhou, Pedro Cabrales, Andre F. Palmer, Simulation of NO and O2 transport facilitated by polymerized hemoglobin solutions in an arteriole that takes into account wall shear stress-induced NO production, Biophysical Chemistry, 2012, 162, 45

    CrossRef

View Full Article (HTML) Get PDF (1178K)