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Formulation and Engineering of Biomaterials
Synthesis and characterization of bovine serum albumin-coated nanocapsules loaded with indocyanine green as potential multifunctional nanoconstructs
Article first published online: 14 OCT 2011
DOI: 10.1002/btpr.732
Copyright © 2011 American Institute of Chemical Engineers (AIChE)
Additional Information
How to Cite
Jung, B. and Anvari, B. (2012), Synthesis and characterization of bovine serum albumin-coated nanocapsules loaded with indocyanine green as potential multifunctional nanoconstructs. Biotechnol Progress, 28: 533–539. doi: 10.1002/btpr.732
Publication History
- Issue published online: 10 APR 2012
- Article first published online: 14 OCT 2011
- Accepted manuscript online: 21 SEP 2011 12:33PM EST
- Manuscript Revised: 26 AUG 2011
- Manuscript Received: 13 JUN 2011
Funded by
- A. Ward Ford Memorial Institute Research Grant from the American Society for Laser Medicine and Surgery (ASLMS)
- Bourns College of Engineering
- Bioengineering Center at University of California, Riverside (UCR)
- Abstract
- Article
- References
- Cited By
Keywords:
- drug delivery;
- optical imaging;
- nanoparticles;
- phototherapy
Abstract
We have synthesized and characterized bovine serum albumin (BSA)-coated polymeric nanocapsules (NCs) loaded with indocyanine green (ICG), an FDA-approved near infrared chromophore. Poly(allylamine) hydrochloride was electrostatically crosslinked with phosphate anions to form nanoconstructs encapsulating ICG. BSA was conjugated onto the polymeric NCs via glutaraldehyde. BSA-coated ICG-containing nanocapsules (BSA-ICG NCs) were characterized by FTIR and optical spectroscopy, SEM, and zeta-potential measurements. Using normal human endocervical epithelial cells, we demonstrate the effectiveness of BSA-ICG NCs for intracellular optical imaging in vitro. These nanoconstructs may potentially serve as a multifunctional platform for combined optical imaging, phototherapy, and drug delivery. © 2011 American Institute of Chemical Engineers Biotechnol. Prog., 2012