The nose is the central feature that defines one's face. Acquired nasal defects arise from a variety of pathologic and traumatic etiologies and reconstructive surgeons may be called upon to restore form and function when the nose has been altered in some way. Nasal reconstruction is one of the most challenging and rewarding procedures performed by the plastic surgeon. A detailed knowledge of the anatomy of the nose – the lining, support and cover – is essential in designing the reconstructive effort. Surgical planning involves, first, identifying the extent of the acquired defect, followed by the application of an intricate knowledge of the tissues that will provide a functional and aesthetically pleasing yet durable reconstruction. In this article, the reader will find a description of the clinically important anatomic features of the nose as they relate to various reconstructive procedures aimed at restoring nasal appearance and maintaining airway patency. Clin. Anat. 25:86–98, 2012. © 2011 Wiley Periodicals, Inc.